The Indo-Belarusian pair was given a scare by Anthony Dupuis of France and Lee Hung-taik of South Korea at the US Open.
The duo are pairing up since their respective partners Max Mirnyi and David Rikl have opted out of the Long Island event.
The top seeds will take on seventh seeds Wayne Arthurs and Paul Hanley of Australia.
Mahesh Bhupathi and his American partner Liezel Huber have been given the top billing at the mixed doubles event of the French Open while Leander Paes and Cara Black are seeded second.
The Indo-Belarussian pair lost to Arnaud Clement and Sebastian Grosjean in the second round at the Miami Masters.
The top seeds beat Gaston Etlis and Martin Rodriques of Argentina in straight sets.
Mahesh Bhupathi and Mark Knowles entered the final of the Monte Carlo Masters with a 6-0, 7-5 win over Jeff Coetzee and Wesley Moodie.
Indian tennis stalwarts Leander Paes and Mahesh Bhupathi, who were locked in a selection row for the London Olympics recently, saw their fortunes take different turns with the former reaching the third round of the men's doubles event while the latter crashed out of mixed doubles competition of the Wimbledon.
Admitting that his pairing with Sania Mirza in the mixed doubles category would have been the best bet for India in the London Olympics, Mahesh Bhupathi on Tuesday said that the Indian star player was used without even being consulted.
The third seeded Indo-Russian pair lost to the US team of Mike Bryan and Lisa Raymond, in the mixed doubles final of the French Open.
Unseeded Bopanna and Rajeev Ram hit seven aces and converted one of seven break-point opportunities to beat Victor Hanescu and Lukas Rosol 4-6, 7-5, 10-4 in 79 minutes. Later in the day, Bhupathi and Llodra also came from behind to oust the fourth seeded pair of Mariusz Fyrstenberg and Marcin Matkowski, winning 4-6, 6-4, 10-8.
Indian captain Leander Paes went down in a close contest against Satoshi Iwabuchi, while Mahesh Bhupathi surrendered tamely against Kei Nishikori as Japan closed the margin to 2-3 in the Asia Oceania Davis Cup round II tie in New Delhi on Sunday. Paes lost 4-6, 6-4, 4-6 to the left-handed Iwabuchi in a dramatic fifth rubber after Bhupathi had folded to a 5-7, 1-6 defeat against Japan's no.1 Nishikori.
Mahesh Bhupathi and Mark Knowles beat Leander Paes and Paul Hanley 6-2, 6-7(8), 10-6 in the quarter-final of the Miami Masters.
India's doubles ace is uncertain whether he and Mary Pierce, with whom he won the Wimbledon mixed doubles, will team up at the US Open.
India's Mahesh Bhupathi and his partner Mark Knowles of Bahamas pocketed the $1,401,000 ATP Dubai Tennis title with a straight set victory over Czech pair of Martin Damm and Pavel Vizner on Saturday. In the final, the fourth seeded Indo-Bahamian pair prevailed over their third-seeded opponents 7-5, 7-6(7) in one hour 48 minutes.
The Indian tennis star exuded confidence of winning a medal in the 2008 Beijing Olympics partnering Mahesh Bhupathi.
The World No. 2 doubles pair beat Australia's Wayne Arthurs and Paul Hanley for their first victory in the ATP Masters Cup.
Sania Mirza has handled her off-court woes with great maturity and is on track for a spot in the world's top 20, Mahesh Bhupathi said.
He goes with Joshua Eagle into the Australian Open firmly believing he can become the first Indian to collect trophies from all four tennis majors.
Fourth seeds Paes and Lukas Dlouhy rallied to a three-set win against Yves Allegro of Switzerland and Fabrice Santoro of France.
The Indo-Belarussian pair take on Jiri Novak and Petr Pala of Czechlovakia, at the ATP Estoril Open.
Veteran Mahesh Bhupathi went out of the mixed doubles competition following a first-round loss.
The Indian challenge in the ATP Paris Masters tennis tournament ended after Mahesh Bhupathi and Leander Paes, along with their respective partners, crashed out of the doubles event following unexpected second-round defeats.
Mark Knowles and Daniel Nestor beat the Indo-Czech duo 6-3, 6-4 in the semi-final of the French Open doubles.
Bidding for their second consecutive Masters title, Mahesh Bhupathi and Mark Knowles moved to the quarterfinals of the Cincinnati Masters after edging past Feliciano Lopez and Fernando Verdasco in a tough three setter.
After pairing up with different partners in the initial months of 2013, Mahesh Bhupathi and Rohan Bopanna have decided to rejoin forces for the rest of the season.
The Indo-Czech pair beat Germany's Andreas Beck and Dominik Meffert in the quarter-finals.
India's Mahesh Bhupathi and his Belarussian partner Max Mirnyi crashed out of Wimbledon after a shock defeat at the hands of Robert Lindsted of Sweden and Horia Tecau of Romania in the men's doubles third round in London.
The fourth seeds were beaten by British wildcards Joshua Goodall and Ross Hutchins in the first round of the Nottingham Open.
Meanwhile Prakash Amritraj and Hyung-Taik Lee of Korea made a tragic exit, retiring midway through their first round doubles match.
Mahesh Bhupathi and Rohan Bopanna advanced to the doubles quarter-finals of the ATP 250 event in Nice, France after winning the first round with their respective partners.
The second seeded pair suffered a straight set loss against Sweden's Jonas Bjorkman and Max Mirnyi of Belarus.
Indian pair of Leander Paes and Mahesh Bhupathi crashed out of men's tennis doubles event losing their quarterfinal match to Swiss duo of Roger Federer and Stanislas Wawrinka in the Beijing Olympics on Friday.
Mahesh Bhupathi had to retire due to a leg injury, forcing the him and his partner Max Mirnyi to settle for the runners-up trophy in the men's doubles at the Monte Carlo Masters. The fifth seeds were trailing 3-6, 0-2 against top seeds and defending champions Daniel Nestor of Canada and Nenad Zimonjic of Serbia.
Immediately after winning the Asian Games doubles gold medal, Mahesh Bhupathi announced the end of his partnership with Leander Paes.
The Indo-Czech duo was beaten 4-6, 7-6, 3-6 in the third round at the US Open.
The Indian pair of Mahesh Bhupathi and Rohan Bopanna upset top seeds Max Mirnyi of Belarus and Canada's Daniel Nestor in a hard-fought battle to enter the men's doubles semi-finals of the Internazionali BNL D'Italia tennis tournament in Rome.
The Indian pair of Mahesh Bhupathi and Rohan Bopanna crashed out of the ATP Madrid Masters after losing their semifinal match to Robert Lindstedt of Sweden and Horia Tecau of Romania in Madrid.
Top seeds Leander Paes and Raven Klaasen of South Africa lived up to their billing and entered the semi-finals of the men's doubles event at the ATP Chennai Open with a hard-fought win over Indian pair of Mahesh Bhupathi and Saketh Myneni.